This is a decidedly non-exhaustive list of projects operating in what might be considered in the open source pharma space, broadly construed. At the moment, there is a focus on neglected and infectious diseases, but all disease areas are in scope. If you'd like to have your project featured, please get in touch.
Axon is a platform for collaborative scientific research built on open source technologies and philosophies. Concentrating cost, risk, and knowledge is bad for science and bad for business. Axon aims to transform research from a costly, risky, closed-door undertaking into an open, distributed endeavor that produces better, faster, cheaper results and encourages wider participation in solving some of humanity's most pressing challenges.
Malaria DREAM Challenge
The DREAM of Malaria project seeks to harness the potential of open challenges for solving computational biomedical problems in malaria, a disease where large-scale computational modeling lags behind other diseases such as cancer. The project aims to use open challenges as means to attract computational expertise conventionally inaccessible to the malaria community so as to accelerate the pace of predictive modeling for malaria basic science challenges and drug discovery.
Nipah Virus Open Research Collaborative
Motivated by open source initiatives for neglected diseases, the Vinod Scaria Lab of Genome Informatics started the Nipah Virus Open Research Collaborative. They are collaborating with laboratories, institutions, and individuals to find cures for the deadly outbreak of the Nipah virus in India, which has claimed numerous lives.
Open Source Malaria
The Open Source Malaria project is trying a different approach to curing malaria. Guided by open source principles everything is open and anyone can contribute.
Open Source Pharma Foundation
The Open Source Pharma Foundation is a non-profit organization based in Bangalore, India that seeks to develop a new paradigm for drug discovery. OSPF seeks to discover new drugs, and a new way to discover drugs. Through conducting clinical trials, creating IT tools, and supporting an open source pharma movement, we aim to work towards an alternative, end-to-end open source pharmaceutical system.
Synthetic Biology for Frugal Drug Discovery
The high cost of drug discovery for microbial diseases like tuberculosis is driven in part by the cost and challenge of experimenting on dangerous pathogens. At the CRI in Paris, we are developing the safe model microbe E. coli as a proxy organism to express and target essential metabolic enzymes from other species. By developing inexpensive, simple and safe drug discovery tools we hope to greatly expand the number of people and places that can participate in the discovery process.
TB Digital Quilt
The TB Digital Quilt is a collection of videos contributed by people across the world sharing their thoughts and experiences concerning tuberculosis. One in four humans has the TB bacteria in their body; TB kills more people than any other infectious disease. The project aims to raise awareness about TB and bring together the global community in support of those affected by the disease. Inspired by the AIDS Memorial Quilt (1987), this project also seeks to make a strong impact on funding and research opportunities for tuberculosis. This is a project of the Open Source Pharma Foundation and Mayo Clinic Center for Tuberculosis.
Universally Available, Ultra-Broad Spectrum Vaccines
Toward Universal Vaccines/ A Protective Layer for Humanity: Ultra-Broad Spectrum Open Source Vaccines to Protect Against SARS-CoV-2 Variants, Other Diseases, and Future Epidemics - Phase 3 Trials and Other Explorations